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Our formula for longevity
SLEEP by With Me Nutrition
Science-backed sleep support for deep recovery, hormonal balance, and resilience
Science-Driven. Human-First. Purpose-Built.
At With Me Nutrition, we believe better sleep is the foundation of better everything — physical recovery, hormonal balance, cognitive performance, emotional regulation, and long-term health.
Yet in today’s high-stress, always-on world, most people are sleeping long but not deep. Chronic stress keeps cortisol elevated late into the night, screens and artificial light disrupt circadian rhythms, and poor nutrition undermines the neurotransmitters that drive restorative sleep.
SLEEP by With Me Nutrition is our science-first answer to that challenge — a precision-formulated, multi-ingredient sleep support formula built from the ground up using clinical research, mechanistic science, and EFSA-aligned health claims.
This is not a sedative. It’s a strategic tool designed to restore the biological foundations of deep, high-quality sleep — naturally.
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Why Sleep Matters: The Most Powerful Recovery Tool You Have
Sleep is not passive rest — it’s an active, highly coordinated biological process that affects nearly every system in the body. During deep sleep, your brain clears toxins, repairs synapses, and consolidates memory. Your endocrine system resets cortisol rhythms and releases growth hormone. Your mitochondria repair oxidative damage. Your immune system builds resilience.
When you don’t reach deep sleep consistently, every major function in your body suffers:
Hormonal balance becomes disrupted, affecting thyroid, sex hormones, and stress response.
Neurotransmitter production declines, worsening mood, focus, and motivation.
Muscle recovery slows, impacting strength, energy, and performance.
Chronic disease risk rises — from metabolic syndrome to cardiovascular disease.
Our mission with SLEEP by With Me Nutrition is to restore order — supporting the nervous, endocrine, and cellular systems that govern sleep from the inside out.
How SLEEP by With Me Nutrition Works
Sleep is orchestrated by a web of neurotransmitters, hormones, and circadian signals. When that system is disrupted, sleep becomes shallow and fragmented. Our formulation targets the four most critical biological pathways to bring that system back into balance:
Neurotransmitter Balance – The Language of Sleep
Sleep onset and depth depend on a delicate balance between inhibitory and excitatory neurotransmitters — particularly GABA, serotonin, and melatonin.
GABA (gamma-aminobutyric acid) calms neural activity, reduces anxiety, and signals the brain to enter sleep mode. Small human trials show that oral GABA taken before bedtime reduces sleep latency and increases non-REM sleep time (PubMed: 30074153).
5-HTP, a serotonin precursor derived from Griffonia simplicifolia, helps replenish serotonin levels and downstream melatonin production, improving sleep architecture (PubMed: 12059028).
Vitamin B6 and methylfolate serve as cofactors in neurotransmitter synthesis, ensuring these pathways operate efficiently.
Together, these compounds rebuild the biochemical “language” your brain needs to transition into restorative sleep.
HPA Axis Regulation – Lowering Nighttime Cortisol
The hypothalamic-pituitary-adrenal (HPA) axis is your body’s central stress-response system. Chronic stress keeps cortisol elevated long after dark — one of the most common reasons people struggle to fall asleep.
Ashwagandha root extract has repeatedly been shown to reduce cortisol and improve sleep quality. A randomized controlled trial found significant improvements in sleep onset latency and quality with standardized ashwagandha extract (PubMed: 31728244).
Magnesium bisglycinate supports GABAergic activity and NMDA receptor balance, promoting relaxation and helping the body shift into parasympathetic dominance (PubMed: 23949742).
Chamomile extract, rich in apigenin, binds to GABA-A receptors, contributing to mild anxiolysis and shorter sleep latency (PubMed: 28495353).
By calming the HPA axis and lowering stress hormones, SLEEP by With Me Nutrition helps your body shift out of “fight-or-flight” and into deep rest mode.
Circadian Rhythm & Endocrine Synchronization – Resetting the Body Clock
Your circadian rhythm is the internal clock that dictates hormone release, body temperature, and sleep timing. Modern light exposure, late-night eating, and irregular schedules disrupt this rhythm — but it can be realigned with the right signals.
Tart cherry extract contains natural melatonin and polyphenols that increase total sleep time and reduce nocturnal awakenings (PubMed: 22038497).
L-glycine, when taken before bed, lowers core body temperature and enhances slow-wave sleep — the most restorative stage of sleep (PubMed: 20347397).
Zinc supports melatonin synthesis and endocrine signaling, further reinforcing circadian balance (PubMed: 22894951).
These compounds act like “reset buttons” for your biological clock, restoring the natural rhythm of sleep and wakefulness.
Recovery & Longevity – Repairing at the Cellular Level
Sleep is when your body does its most important repair work — repairing DNA, clearing damaged cells, and restoring mitochondrial function. Optimizing this window is key for long-term resilience.
Myo-inositol supports serotonin signaling and insulin sensitivity, reducing blood sugar spikes that can disrupt sleep (PubMed: 34825232).
Apigenin, a flavonoid found in chamomile, has neuroprotective and anti-inflammatory effects, reducing neuroinflammation that can interfere with sleep (PubMed: 30041570).
BioPerine®️ (black pepper extract) enhances the bioavailability of botanical compounds, ensuring maximum absorption and effectiveness (PubMed: 23441720).
SLEEP by With Me Nutrition isn’t just about getting to sleep — it’s about transforming what happens while you sleep.
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A Formula Built on Evidence, Not Trends
HUMAN-FIRST APPROACH
We prioritize ingredients and doses with published human data.
MECHANISTIC DEPTH
We target the actual biological systems that regulate sleep, not just symptoms.
TRANSPARENT SOURCING
Every extract’s origin, standardization, and purpose is disclosed.
LIVING SCIENCE
As new studies emerge, we update our understanding and formulation accordingly.
SLEEP by With Me Nutrition is not about masking fatigue — it’s about restoring the biological systems that keep you resilient.
Ingredient Science
The Research Behind
SLEEP by With Me Nutrition
Every ingredient in SLEEP by With Me Nutrition was selected based on human data, mechanistic research, or EFSA-backed health claims. This is not a random blend — it’s a formula engineered to restore the deep biological processes that govern sleep, stress resilience, neurotransmitter balance, and overnight recovery. Below, you’ll find the science behind each key ingredient.
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Clinical Roadmap: Our Commitment to Ongoing Research
Our mission doesn’t stop at ingredient science. We are actively developing a roadmap for finished-product clinical trials on Sleep by With Me Nutrition. Planned study endpoints include:
Sleep latency, total sleep time, and sleep stage distribution (via polysomnography and actigraphy)
Heart rate variability (HRV) and autonomic balance
Salivary cortisol (AM/PM ratio)
Next-day cognitive performance
Mood, resilience, and perceived stress scores
Our goal is to publish results in peer-reviewed journals and share them openly here
